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Off Episodes hero image

Are Your Parkinson’s Patients Experiencing OFF EPISODES More Often Than You Think?

HOW MUCH TIME do your patients spend waiting for ON?

Graph of delayed on time and end-of-dose wearing off

Time to ON

The latency from taking an oral levodopa dose until the patient turns ON1

Wearing OFF

The time from termination of the beneficial effect of the dose until the time when the next dose is taken1

With disease progression, OFF time can account for up to 50% of a patient’s waking day.2

  • At any given time, an estimated 468,000 people with PD in the US experience OFF EPISODES3
  • In a survey, more than 3,000 people with PD reported the impact of OFF EPISODES in their daily lives4
More than 90%

have at least one OFF EPISODE per day4

About 65%

were OFF for >2 hours per day (more than 59 hours per month)4

About 50%

said their OFF times cause them to avoid or stop activities they can perform while ON4

  • OFF EPISODES interfere with a patient’s day-to-day life5

Mobility and motor symptoms5:

  • Tremor
  • Balance
  • Slowness
  • Dystonia
  • Stiffness, etc.

Complicate everyday life5,6:

  • Eating
  • Writing
  • Dressing, etc.


  • Withdrawal
  • Embarrassment
  • Increased reliance on others

There are no APOKYN studies showing that treating OFF episodes affects these specific outcomes.


Delayed ON8,9

Slow onset of oral levodopa—up to two times as long as the duration of wearing off

Dose failure9

Oral levodopa dose produces no noticeable effect

Unpredictable OFF9

Sudden periods when PD symptoms recur

Suboptimal ON9

Oral levodopa dose provides partial effect

Wearing OFF8,9

The effects of oral levodopa wear off prior to next scheduled dose

Morning akinesia2

Delayed or failed onset of effect of first morning dose of oral levodopa; often the earliest manifestation of motor fluctuations9

Consider APOKYN for your patients' acute OFF episodes.10