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APOKYN: Demonstrated Tolerability1

Most common adverse reactions (incidence ≥10%)1

Adverse reaction APOKYN (n=20) Placebo (n=9)
Yawning 40% 0%
Dyskinesias     35% 11%
Drowsiness or somnolence 35% 0%
Nausea and/or vomiting 30% 11%
Dizziness or postural hypotension 20% 0%
Rhinorrhea 20% 0%
Chest pain/pressure/angina 15% 11%
Hallucination or confusion 10% 0%
Edema/swelling of extremities 10% 0%

Discontinuations due to nausea and vomiting in an open-label, long-term study of APOKYN use (N=550):

Overall incidence of nausea was 31%; 3% of patients discontinued treatment.1

Overall incidence of vomiting was 11%; 2% of patients discontinued treatment.1

Pretreatment with antimetic (eg, trimethobenzamide HCI) is recommended, not required.1